What Is Pain?
The widely accepted definition of pain was developed by the International Association for the Study of Pain. Pain is an unpleasant sensory and emotional experience associated with—or described as—actual or potential tissue damage.
What Is Neuropathic Pain?
Neuropathic pain is pain that results from direct damage to nerves due to various causes.
Neuropathic pain, resulting from damage to nerves in the peripheral or central nervous system, is chronic. It manifests as symptoms such as burning, stabbing, tingling, numbness, electric shock-like sensations, or freezing, and these symptoms negatively impact the person’s quality of life.
The underlying condition causing neuropathic pain must be treated. For example, if diabetes is the cause of neuropathic pain, it is important to keep the patient’s blood sugar under control.
Treating neuropathic pain can be challenging, and many analgesics may prove insufficient in relieving the pain. Damage to the protective myelin sheaths surrounding the peripheral nerves leads to symptoms known as “peripheral neuropathic pain.”
What Is Uridine Monophosphate?
It is a valuable building block found in all living organisms.
The primary active ingredient in uridine monophosphate is uridine. Uridine is an essential substance required for the formation and repair of cell membranes.
Various clinical studies have shown that uridine monophosphate supplementation supports the maintenance of the healthy structure and function of nerve cells.
What Is Prologinoline Quinone?
It is a substance commonly found in fruits and vegetables such as apples. It helps facilitate chemical reactions in the body. It ensures the mitochondria (the organelles that provide energy to the cell) function more effectively. It protects nerve cells.
What Is Cobalamin (B12)?
Vitamin B12 is a water-soluble B vitamin that is essential for nearly every cell in the body due to its role in DNA synthesis and the utilization of fatty acids and amino acids within the body.
It is essential for nervous system health, brain function, and red blood cell production.
What Is Folic Acid (B9)?
It plays a role in the production of nucleic acids in DNA and in the formation and proliferation of blood cells.
Folic acid plays a particularly important role in the development of the nervous system.
What Is Choline?
Choline is a nutrient essential for nutrition and is part of the B vitamin group.
It is a molecule necessary for the production of acetylcholine, which plays a vital role in nerve signaling. When the body lacks choline, many cells and organs—particularly the brain and nervous system—cannot function properly.
The main benefits of choline:
• Regulates the brain and nervous system.
• Supports liver health by reducing fatty liver.
• Helps lower blood pressure and cholesterol.
•Improves memory, as it is a building block of acetylcholine.
•Has a positive effect on mood.
What Is Alpha-Lipoic Acid?
Alpha-lipoic acid (ALA), a fatty acid that plays a role in energy metabolism within cells, is an organic compound found in all human cells. Synthesized within the mitochondria—the cell’s energy production center—alpha-lipoic acid also functions as an antioxidant that helps prevent inflammation and aging.
The body’s production of alpha-lipoic acid decreases with age. This leads to an increase in damage caused by free radicals within cells.
Alpha-lipoic acid has been shown to help regulate blood sugar and cholesterol levels.
Scientific studies have proven that alpha-lipoic acid is effective in treating diabetic peripheral neuropathy associated with diabetes.
References:
Cansev M. Brain Research Reviews. 2006 Sep;52(2):389-97. Pooler A.M. Neuroscience. 2005;134(1):207-14. Wang L., Brain Research. Feb 16, 2007; 1133(1): 42–48. Sakamoto T. Brain Research. Nov 28, 2007;1182:50-9.
Luis Negrao et al. Uridine Monophosphate, Folic Acid, and Vitamin B12 in Patients With Symptomatic Peripheral Entrapment Neuropathies. 2016;6(1):25–9
V Gallai et al. Effects of uridine in the treatment of diabetic neuropathy: an electrophysiological study. Acta Neurol Scand. July 1992;86(1):3–7.
Marco Antonio Mibielli et al. Symptomatic improvement in an acute, non-traumatic spine pain model with a combination of uridine triphosphate, cytidine monophosphate, and hydroxocobalamin. Pain Studies and Treatment Vol. 2 No. 1 (2014), Article ID: 42000, 5 pages